Multicentric Gorham's disease

Gorhams disease: vanishing bone syndrome.

Gorhams disease, also known as massive osteolysis or vanishing bone disease is an extremely rare bone disease. It is characterized by angiomatosis with adjacent bone resorption. We report an 8-years old boy with the disease who was managed successfully with alpha 2b interferon therapy.

Multicentric Castleman's disease and HIV.

Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder found with a higher frequency in HIV-seropositive patients. Human herpes virus 8 is found in virtually all cases of HIV-associated MCD. The majority of cases of MCD in patients with HIV are also associated with Kaposi's sarcoma. The dysregulated production of human IL-6 is thought to be an important factor in the path...

HIV-associated multicentric Castleman's disease

Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder. It is found with higher frequency in patients with HIV infection, with systemic symptoms and poor prognosis. We present the case of a 32-year old man with HIV disease, Kaposi's sarcoma, lymphadenopathy, fever and hemolytic anemia. A diagnosis of Castleman's disease is confirmed through biopsy and treatment is often b...

Healing of erosive disease in multicentric reticulohistiocytosis.

Multicentric Bowen disease in linear porokeratosis.

Linear porokeratosis is a genodermatosis, caused by a clonal proliferation of keratinocytes along the lines of Blaschko. This type of porokeratosis is particularly susceptible to malignant degeneration e.g. to Bowen disease, a squamous cell carcinoma (SCC) in situ with the potential for significant lateral spread. Here we report a case of linear porokeratosis on the left leg of a 56-year-old ma...